Donor Variables as Major Determinants of Platelet Yield in Plateletpheresis

Abstract

Objective: To identify the major donor variables that can affect the platelet yield so that improvement in donor selection criteria can be suggested.

Methodology: This is a cross-sectional study conducted at the Department of Hematology, Chughtai Institute of Pathology May 2022 to May 2023. A total of 116 male donors were recruited in the study. The procedure of plateletpheresis was performed on Cobe spectra, Fresenius Kabi, Trima Accel or Spectra Optica. Platelet yield was calculated and data was analyzed using SPSS 23.00. Relationship between continuous donor variables and platelet yield was studied by using Pearson coefficient. For categorical donor variables one way ANOVA test was used. A p-value < 0.05 was considered significant.

Results: No significant correlation was seen between platelet yield and donor´s age, weight, hemoglobin levels, blood group and Rh factor. However, a significant correlation was observed between total pre-donation platelet count of the donor and platelet yield.

Conclusion: While factors like age, weight, and blood group showed no significant correlation, pre-procedure platelet count strongly influenced platelet yield. Donors with higher platelet counts yielded more platelets, emphasizing the importance of donor selection based on platelet count.