Successful Pregnancies in a Case of Severe (Type 3) von Willebrand Disease

Abstract

Given the wide heterogeneity of phenotypes and the underlying pathophysiological mechanisms associated with the disorder , pregnancy and delivery in VWD represents a significant clinical challenge . The variable pattern of changes observed during pregnancy in von willebrand factor (VWF) and factor VIII (F-VIII), the protein carried by VWF , prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition. ¹Women with von Willebrand Disease (VWD) are at an increased risk of bleeding and other complications during pregnancy and childbirth.^2,3Women with inherited bleeding disorders, including VWD, are concerned about their bleeding and possible bleeding complications. All these leads to upfront efforts to give this cohort a safe   reproductive fruition .Last 20 years have witnessed progression in understanding diagnosis, and treating complications in women with VWD .^1-6