Platelets Indices as Biomarkers of Glycemic Control and Progression of Complications in Patients of Diabetes Mellitus Type II

Abstract

Objectives: The main objective of this study was to analyze various platelet parameters among diabetes mellitus type patients (without and with complications) and controls.

Methodology: It was a prospective, cross sectional study, carried out at Dept. of Pathology and Dept. of Medicine, Indus Medical College Hospital, Tando Muhammad Khan. Complete blood count (CBC), serum glucose levels, and HbA1c were evaluated. All participants were divided into three groups: Group 1: Normal Controls (n=35); Group 2: DM type II patients without complications (n=35); and Group 3: DM type 2 with complications (n=35). Patients were also categorized as good and poor glycemic control (HbA1c <7% and HbA1c >7% respectively). All data variables were analyzed with SPSS 21.0. ANOVA test was applied to see the significant correlation. P value of <0.05 was considered statistically significant.

Results: All platelet parameters including mean platelet volume (MPV), platelet – large cell ratio, platelet distribution width (PDW), and plateletcrit and were significantly altered among patients of DM type 2 with complications as compared to other groups.

Conclusion: This study demonstrated higher platelet indices among diabetes mellitus type 2 patients. Our results postulated simple and cost – effective tool for monitoring of progression of complications in diabetic mellitus type 2 patients.